I shot a cow square in the front quarter from about 75 yards with a Barnes. Not the best shot I could have made but she wasnt exactly standing still for me. She only made it about 50 yards but I could not find a blood trail leading up to her. The front quarter was completely destroyed, no muscle worth saving. A friend on the same hunt used the same bullet (heavier grain) out of his '06 on a cow at 250 yards. He had the same complaint about no blood trail. He had a good lung shot and she still went a couple hundred yards through some nasty blow downs. Lack of snow made the tracking tough but I was expecting a better blood trail. This was about 7 years ago and I havent tried a Barnes since.