I've considered this in the past. If I lived in a state that did not allow rifles for deer hunting, and if I wasn't a handgun hunter, I'd go with a muzzleloader over a slug gun. Besides the fact that it would allow me to hunt during muzzleloader seasons in addition to gun seasons, I've found modern inlines to be 1.5 to 1 MOA capable with a bullet/sabot/powder combination they like. With a 120 to 150 grain powder charge and the appropriate bullet, they've got more than enough power to kill a deer out to 300 yards if you can account for the drop.