have to point out a fact that all too many guys either ignore or never considered,
the projectile does ALL the work and damage! where you hit on the animals anatomy,IS CRITICAL
rapid lethality depend on where you place the projectile and how much damage is done.
and how much damage to vital organs and/or skeletal structure,being done,
should obviously be considered the major factor in potential lethality expected.
small fast expanding projectiles are devastatingly lethal... IF placed correctly,
IF THEY destroy the heart/lung area but the deer can still run very fast and
well for up to 10 seconds or so , and they may not leave much of a blood trail,
larger more heavily constructed projectiles, like a 180 grain 30 cal, or a 250 grain 358 bullet open slower and in a far more controlled manor ,
they may not do as much damage to the lungs,initially but they are 100% lethal if shots are well placed.
and frequently leave a blood trail.
and they do tend to be much more consistent and reliable at busting skeletal structure,
provide deep penetration through muscle and they do tend to leave exit wounds more often.
if you hand-load you can custom fabricate ammo specifically matching your requirements.
traditional brush cartridges like a 45/70 or 444 marlin can provide exceptional penetration,
(especially if loaded with heavy for caliber cast bullets,)(these can be depended on to exit deer )
or be loaded with fast expanding hollow point bullets to give rapid expansion.
(1) where you place the shot is critical (know the games anatomy)
(2) use of a heavy for caliber projectile tends to greatly aid deep penetration
(3)the larger caliber and heavier the projectile, used the more consistent deep penetration
(4)deep penetration is a plus only if you use it to destroy vital organs,(heart/lungs)
and
critical structure like spine and shoulders, (see #1)
Ive used or seen guys I know use most common caliber rifles
if your using anything pushing a premium quality bullet that has a .210 or higher sectional density,
to over about 2300 fps
that weights at least 100 grains, and not getting decent results, on deer,
your issue is related too less than ideal shot placement in most cases
https://www.beartoothbullets.com/rescources/calculators/php/density.htm?bw=250&bd=.356
https://youtu.be/aYk6cQx5qJ4