Using my Nikon Spoton software (which is pretty accurate, I've found) you'll end up hitting 3 to 6 inches high at 100 if you sight in at 13 yards with a 50 cal inline firing 250 grain Shockwaves. There might be a combination of muzzleloader, bullet, and powder charge that will be zeroed at both 13 and 100 yards, but honestly, I'd just prefer to get it on paper at 25 and 50 yards then fine tune the sights to 100.