The right 22 mag ammo will drop them dead..as long as your shot placement is good...but to get within 50 feet of a yote your either hiding in a dead cow carcass with a shoot hole..or he is blind and his nose fell off...
I have a Ruger V77 22mag rifle which is deadly out to 100yrds if you do your part..
best ammo I have shot was the CCI game point..or the V Max...or the Winchester Supreme or super x
I have taken yotes out to 90 yards ..some DRT or dead in 20 yards...a bi pod or shooting sticks help alot to get the steady eddie shot...on the Predator forum there are guys shooting boar with head shots at 50 yards with a kill...