Way back in the day I was doing some critter control work at a very restrictive locale and had to be selective on what I could use. I took my 22-250 and loaded it down with 45grn Sierra Hornet SP's and I cant remember the powder but had to use a tuft of filler to keep the powder charge flat and they shot great out to 150yds. No sight adjustment at all. Dead on. So, with that being said, it can be done as others have said, just go to Hornady or Sierra website. Or call them directly and tell them what you want to do and they should be able to help you out.