I have harvested with a 30-06 and 300 weatherby mag. I have used a 6.8, 50 Cal ML, 30-30, 257 weatherby mag. I currently own the 257 wby vanguard, 6.8, and ML. That's all. Eventually I want to upgrade my weatherby to an Accumark in the same cartridge. Even though I haven't harvested anything with it, the cartridge is amazing. The new 6.5-300 wby mag they just came out with looks bad to the bone.