My basic rule is if the animal stands there, I'll send another round downrange. But if it runs and it was a clean miss I normally hold fire. After all if I blew the first shot at a motionless animal I would probably blow the shot on a moving animal. The odds of wounding on a moving animal are a lot greater that in it is standing still. However, if I think the first round hit and the animal is moving I'll shoot again immediately. I guess I would have to take it on a case by case basis. I wounded and lost a big bull elk once by taking a shot I should have held off on. Learned my lesson.