Too much Angle can cause the problems You mentioned.....I've used a 30-06,.243,7mm-08 all with no issues!Be sure to wait for a good broadside shot,shot just back and behind the front leg for a lung shot or even a little lower to get the heart.Some go for a head shot but I'd rather not,others go for the shoulder shot to anchor a Deer quicker but that can cause a lot if meat damage too.

I use the Remington Core-Lokts in the 30/06,7mm-08 and Hornady Custom 100 Grainers in the .243 with great results....high shots from a tall stand would cause serious damage on the upper part of a Deer in the loin area if Your angle is pretty steep.You need to take into consideration of the Angle of Your shoot and where the Bullet will exit after passing thru,kinda like Bow Hunting visualize the angle of the Deer and where Your shot placement will be and where it will enter then exit and wait for the best shot opportunity!