This is why consistency in processes and materials at the baseline and load development are so critical.

When I was younger and didn't take the time to understand, I'd whip out 100 rounds at a time of a load I had no idea would work well or not (hey, they had good bullets in them, though). Generally, they didn't work well. Once I figured out I had quite a bit of slop in my processes in general, and once I started load development in earnest, I'll generally find a "sweet spot" with just about every bullet/powder/primer combination.

My last effort was with .22-250, Varget, and 50gr V-Maxes. One load grouped (two groups of five rounds - three rounds doesn't give you enough feedback) averaged just over 1.1" at 100 yards. Not going to work on Prairie Dogs at 300. But a different charge of the same powder a few rungs up the ladder turned .46". I had yet another charge that turned .51".

Consistent processes and commitment to load development will help you squeeze the most out of your reloading operations.