Both are awesome calibers and you wouldn't go wrong with either one. I've been shooting a 25.06 for over 20yrs with great results and my daughter shoots a 260 with equal results. We handload and both cailbers are very accurate and on game performance has been excellent with both. Having said that let me add that if i could only own one it would be the 25.06 and the 260 would be my second choice. Mike