Guys---For the OP, you need to use a 410 slug, as I don't believe there is anything else big enough for the 410 to take a coyote cleanly!

For kevin 2---The shot you are suggesting on using in the 28 gauge is for small game and they are not going to do anything but wound a coyote unless he's right on top of you. Even suggesting 50 yards is ridiculous, as it's not even for small game at that kind of distance for the most part. Find a slug that is accurate in that 28 gauge if you want to use it on coyotes, just like I mentioned on the use of a 410.