Yep
Common 45/70 load data and 50cal MLs can produce similar velocities. The Savage can easily exceed a 45/70 except for maybe Ruger #1 load data. The 458-325gr FTX is a good choice if you want a higher BC and still get reliable expansion down to about 1300fps.
Retained about 250gr
http://www.youtube.com/watch?v=83y1ezzHznM
It will rock you a little bit too though.