45 is plenty for deer, black bear, turkey...some have taken elk and moose with that poundage and lighter.
Draw weight is only one part of the equation. 2117's will likely be too stiff unless you go way heavy with your points.
Good arrow flight is essential to good penetration--a wobbly arrow kills penetration.
The Sage is a dandy bow--you could do a lot worse and spend a lot more money doing it.
Chad