I hunted with my Renegade this for elk. It has a GM 1-70 twist barrel (.54). The season was last week. I used 85gr of Swiss 2F powder and a PRB. I killed a cow at 70yds, and it piled up at 50yds. It weighed at least 200lbs more than any mule deer alive. The shot knicked the heart and busted through both lungs. Tracking was pretty easy, because it never went out of sight.
I used a load that I knew the gun shot well. I shot a distance that I knew was effective for my load. I also took a shot that I knew I could make.
I plan on using the same thing for deer in rifle season.
I loved the challenge, and I still smile thinking about the hunt. Probably the most enjoyable hunt i've had in 60 years of hunting.