At 250, you'll probably be an inch or two low, but not enough to worry about. From 250 to 300, I'd say you might hold about 2/3 up on the deer's body. As I said, you just have to play around with it to know for sure. I handload, so my loads won't be just like yours, etc. I have shot at my 400-yard target with at least 5 different rifles, and friends have shot several of theirs, and no two are exactly alike. If your rifle/load combo is accurate and your certain of your zero being 2 inches high at 100 yards, I would think you'd be safe out to 300 as is. I would want to do some experimenting before attempting anything past 350 though, because even the flat shooters start to fall off quick out there.