I shoot a 50 lb. bow with Easton XX75 2215's and 100 gr. 3-blade Muzzys. Pretty slow by today's standards, but it makes for a quiet and forgiving setup, plus I have no problems pulling it back and holding it even when I'm half frozen. Pass throughs if you punch the ribs at 20 yards. I wouldn't want to take my rig out West, but for eastern hardwoods whitetails, it will get the job done.
What you lose is the ability to punch through a shoulder if you are a little off, so practice and choose your shots wisely, as hopefully we all do.