I have been using a 22-.250 for deer hunting for over 10 years and dropped over 100 white tail and mule deer, boar, a bear and countless amount of varmints and the most anything ever moved was the first boar I shot ran 50 yards...... And I also have a 270 and a 338 lapua in the closet at home but I just find the little 22-.250 ackley alot more fun. I fully agree with using them as long as the right person is using it. Some people say they shouldn't be used over 200 yard but they have alot way past that.