I have a Ruger Mark III 22/45 and its awesome. My F-I-L and B-I-L both went out and bought one after they shot mine. It went 700 rounds before its first malfunction and that is ounly because I wanted to see how long it would go before needing its first cleaning. I can stand at 20 yards and put 25 rounds into an 1'' to 1.5'' off hand and I am not that great of a pistol shot so its very accurate. Go with the Ruger and don't look back.
