I believe on medium sized caliber can do it all with different loads. Unless were discussing claiming meat on small game of squirrel size so mine is.
Small
.270 win with 110 vmax
Medium
.270 win with 110 Accubond
Large
.270 win with 140 Accubond
Dangerous
Id love to try and take dangerous game with a .270 and 150 partition but if a minimum caliber as in Africa is imposed then .375 H&H