For home protection I really like the 45 Auto. Anybody else in the house with you?? No need for high capacity in your own home, you are not likely to spray and pray with family members in the house.
I keep my 45 Colt(revolver), and my 1894 Marlin in 45 Colt as my home protection firearms. I load my own ammunition, but I do not use reloads in my defense ammunition. I use a good factory load that I can use in both firearms.
I do have a couple of 1911's in the safe, as well as a new S&W M&P45, and I believe they would be just as effective for home protection as my 45 Colt. I just stay with the 45 Colt because I shoot the same ammo in my home protection lever action rifle. So this keeps things simple. I really like my lever action for home protection. I had the barrel chopped to 17". Short, Sweet, and FAST. Tom.