In the past 40 years i have killed over 200 deer using 150 grain .30 caliber Sierra Game King and BTSP bullets. Those bullets do have their limitations: As mentioned previously, do not shoot as deer in the shoulder with a Game King.
When a deer is hit behind the shoulder with a .30 150 Game King at high velocity; the inside rib cage opposite the point of impact will often have an exit hole surrounded with a shotgun like pattern of small holes from bullet fragments.