Again, I am going to say this as plainly as I can.
The 22 hornet was never designed to shoot long, sleek bullets. It was designed to shoot very light weight bullets with very short ogives which makes a very short bullet. The 1 in 16 twist is more than acceptable for the intended purpose of the cartridge when it was designed.
A short and fat 35 grain bullet designed for the hornet.
A long and sleek 40 grain bullet for the faster 22 centerfires but should still be plenty stable in the hornets 16 twist.
A long sleek 50 grain bullet that likely would not be stable in the hornet.