I use both the 25-06 and a .243. Of the two the 25-06 is far and away my favorite for both coyote and deer. My 25-06 kills deer quicker then any gun I ever owned. I reload with Barnes100 TSX bullets and push them to the max (3450fps). The all copper bullet doesn't tear them up to bad either. Here is a picture of an exit hole on a coyote.
