If I wanted to jerk ya around I'd say point the darn gun at the tree and shoot... but it seems you're wanting real advice. I've been an avid squirrel hunter for the better part of two decades. I've never seen a year like this year. They're all over the place. Basically, in the first part of the season I'll do kinda a still hunting technique where I work an area where I know there are squirrels listening for them to cut on nuts or scan the trees for what I consider "squirrel type" movement in branches. Wind is pretty constant but when the branches are moving and shaking all over the place more often than not its not the wind. During the late season it gets harder. You're shots are bound to be farther and you're more apt to get shots on the ground rather than in trees. The can also see you alot better. I typically go for a weapon that will give the farther shots as an option. Last weekend, I was deer hunting on a ridge top and wound up bagging out on saturday. Sunday I took my 17 hmr and limited out. There is a book called the ultimate guide to squirrel hunting by bob gooch, I've found it helpful.
If you told me a little more about your usual hunting stratagy for them I may be able to tell you more. Ultimately, I recommend studying up on any game you pursue, the different plants that it may eat, etc before you go out looking for a hunting experience. So give me some more specific questions (you can pm if you want) and I'll give my take on it anyways.
Ultimately just point the darn gun and shoot.