I would go to the source, the guides. Most of them are going to be happier to see you with a gun you shoot well than a big ass gun you cant shoot for beans. Sure, a .375 makes a big hole...where it hits. Will you honestly be able to shoot it frequently enough (both financially, physically be ablt to deal with the recoil and blast, and focus on the shots)to be as proficient with it as if you spent the money on a stack of good premium ammo for another proven gun, like a 30-06 or .300 win mag which is also well proven on big bears? More to it than just the "glory" of the big gun...