I prefer to handload my .308 165 gr. speers, but in all honesty according to the chronograph, I am shooting standard velocities. I have never shot hornadys in the .308, but have shot many from my 30-30 with excellent results. Thier projectiles are great quality, and it all boils down to putting the round in the right place. For bench rest shooting you may do better matching up certain bullets, but for field accuracy, what ever you find works. There is no such thing as any one round that will guaranteed put an animal down in its tracks every time (barring 100% placement in the brain). Accept that some animals even when perfectly hit will run a bit. It doesnt mean you have anything wrong in your round. Pay attention to where they run, listen, and track (usually very short distances). Part of the game. A 130 grain .308 wont cut it on heavy northern deer except brain shots.