In then hands of a good marksman, marksman being the key word here, a 7mm mag will take down anything that walks on two or four legs on the North American continent....PERIOD.

I hunt the deep south with a 30/06 where most shots are 25-75 yards, and I often aim for the neck. There is no meat loss and they drop where they stand. BUT...if the animal is walking or I don't have a really clean shot, I go for the vitals. NEVER lost an animal, but I have also let many walk or run by because I wasn't 100% confident in the shot.

I truly strive for 1 shot 1 kill.