RE: .243 Big Game Animals
I would think with proper shot placement it's more than capable. I wouldn't try alot of angle shots through shoulders. But saying that any fast caliber can bounce off bones at bad angles. I have personally seen a deers shoulder blade turn a 300win mag. The deer was up hill and just enough of an angle to send the bullet out the withers of the deer. Second hunter killed the buck so we got to see the recourse of angle shots gone wrong. Stay behind the shoulder in the heart and lungs dead animal everytime. And if you don't have that shot, do you really think you should of pulled the trigger in the first place?
Like all things it's the operator not the tool that makes the difference. Some hunters need 105 howitzers. Just sayin.