Myself I work with 3 powders and one bullet at a time. Like right now I am working with Scirocco II 180gr bullet with IMR 4350 -H414 and Varget. I have already used the same 3 powders with Scirocco II 165gr bullets and Nosler Partition 180gr. When I get a few groups that all seem to shoot a pretty good 3 shot group I will try to tweak them by going + or - 1/10thgr increments with the powder and maybe try different primers or seating depths to see if any of my best groups close up even more. If I don't get a load I am sastisfied with then I will try a different powder or different brand of bullet and repeat the process. I shoot 3 shots groups and let cool between each 3 shot group. I take the maximum load and drop back 3gr for my starting load and load in .5gr increments (and I keep checking for pressure signs as I go)so I am only dealing with about 6-7 different loads per each powder per each bullet typeor about 20-21 cartridgesper each powder per bullet type. I clean after I am finished but I am only shooting 20-21 shots not counting 2 fouling shots. If you would be shooting 30 or more shots you may need to clean somewhereduring the process.