I would agree with the 243 croud.Hornady makes a V-max 58grain ammo for it that travels at 3760 fps thats faster than most 223 loadings and equal to standard velocity 22-250 loads,but the 243 does it with a heavier bullit than the other two could use to acheive this velocity,thus having more energy at the impact.So you could dust a coyote as far as you could hit it.Then on your Oregon deer hunt you can easily find several 80 to 100 grain factory loads or if you handload you can go a little heavier to 110 grain bullet or so and have a very capable 300 yard deer rifle.I have two 243's that shoot the 58 grainhornady and the 95 grain federal fusion very well.If ammo cost isn't a concern this would be a great caliber.If you wanted something cheaper to shoot a 223 would do the varmint part good and I have killed a few deer with it,but your effective range as a deer rifle would be cut down considerably and neck shots would be more effective for the 223 on a deer,body shot can kill with it but you need to hit them good as with any rifle.243 ammo 12.97- around 30 dollars for 20rnds.223ammo-5.49 for UMC 45grain hollow point 20rnds upto about 29bucks for balistic tip winchester 20rnds.I shoot blackhills 55 grain soft point for about $29 for 50 in my 223.The 243 would be a good dual purpose rifle for varmint and deer.the 223 would work for both, but the 243 would do it better!!