I usually start out testing for accuracywith most .50 cal loads at around 80 grains ffgGoexor PyrodexR/S. Many times I've worked up only to drop back to that load for best accuracy. I feel like that charge behind any projectile from 250 grains up is a serious deer load within reasonable ranges. If I'm expecting to push distances much beyond 100 yards I might jump up to 100 grains of powder, but that's about as high as I usually go. With shots out to 125 yards I've never found it to be too light. The deer always drop if I put the bullet in the "boiler room".