I have just started huntin' yotes and I have a special gun for them -- where I am at it is not uncommon to see 3 to 5 of them at one sitting so I have acquired a bushmaster m4 orc with a 6x24x50 scope because the shots are usually 75-150 yds on multiple targets. using a 55 gr.psp doesn't do to bad a job on the pelts that I have noticed compared to a .243. If the shots aren't going to be very far ( 50 yds or less) I would go with a Marlin .22 mag. or similar.