Have a savage 10 FP in 223 that will drive tacks and just got a model 12 in 22/250,haven't had it long enough to work out the right load but it shoots pretty good too.
The model 12 is a little heavy for a carry rifle so I got a rem sps in 22/250 for that and it shoots great also.
The 243 would be good for deer and varmits.