I've used a 308 since 1988 and it is my caliber of choice for Maine. I'll go out on a limb, get blasted, but I think the 308 is the best choice for all northern New England hunting. Short action, every mom and pop store sells ammo, good bullet selection, less recoil than the 06, and it will kill anything that walks here in NE without a lot of fuzz. I hunt woods but if you hunt in clearcuts or fields it will also get the job done. Nearly every one I've shot has been accurate. Like Quilly I use either 150s or 165s in mine with nearly equal results.

I've killed everything from fox to moose with mine and don't have any complaints. If you need something bigger than go to a 300 or larger.