Last fall I killed nine mule deer with nine shots from the 270 with Federal Fusion 130 grain bullet. None went more than 20 yards most dropped in their tracks. I have done the same thing with the 308 and 6.5x55. No deer ever hit with my wifes 250 Savage ever got away either. Hit them where it counts with any decent caliber and they are going down. Hit them wrong with any caliber, even the biggest whiz bang magnum and you will loose them.