RE: Need cable slide help.
It certainly can effect the bows tune and the way it shoots. Where the string and cables cross varies from one manufacturer to another and some will vary model to model.
I know BowTech recommends all their bows cross below the rod which will make the buss cable go in the deep slot on a single cam and on a dual the buss cable with the split on the top will go in the deep slot of the slide. Either one should have then deep slot facing towards the rear or towards the shooter if you will.
You may want to either specify what bow you're asking about or contact the bow manufacturer to see what they recommend.
I hope this helps...