Personally, I would not use a 22-250 for anything except Southern deer, particulary those low quality tiny Florida deer! Ya see, up here in the magnificent North, where the deer are burly and have 16 inch guns,... and DEMAND respect...

Naaa. JK, The 22-250 with a good shot and decent bullet will do the job within reason.....extreme distances or any situation where the shooter isn't confident about calling the shot should be avoided with any caliber, including the 22-250, but one of my pet rifles is the .243, so I'm sure that in the hands of some the 22-250 would be fine.