I don't think you fill find any discernable difference between W-296 and H-110 in Magnum handgun cartridges. As for Unique, it was the first powder I used for handgun reloading about 25 years ago and while it still is a good choice, it does burn a little on the dirty side. I have used many others such as Accurate No. 5, Accurate No. 2, Winchester 231, HP-38, Hodgdon HS-6, Clays, Universal Clays and Tite Group. My current favorite for loading 9mm, .38 Special and ..357 light to mid range loads would be Universal Clays which seems close to Unique in burning rate but cleaner. For heavy magnum loads, I still have a couple of pounds of W-296. If I felt like experimenting further, I would take a look at Ramshot True Blue.