RE: 22-250 vs 7mm-08
Like everyone else is saying, what will this gun be used for?
Varmints you can't go wrong with a 223, 22-250.
Deer sized critters I'd step up to the 243 or 7mm-08.
Only problem with a 7mm-08 is ammo availability, I know I would have to drive at least 60 miles at home to buy ammo for it, where-as I could buy 223, 22-250, 243 ammo 11 miles from home.