The higher the let-off the easier it is to torque the string, or effect it at draw. This can make you less accurate. higher let-off usually gives the bow a more noticeable "bump" at the end, because you are going from peak weight to nearly nothing. (Not all bows have a draw cycle like that, but when they do, I find it more difficult to hunt with them) I prefer a smooth draw. Normally a higher let-off will have a shorter valley, leaving less room for creep. You may also lose some speed, but from what Ive seen and heard, the speed loss is so minimal its not even worth considering.
High let-off does have its advantages though, you can hold steady for longer. (So this can help you acheive greater accuracy, possibly cancelling out the effects mentioned above) As you can imagine this would prove very valuable in a hunting situation.
If it were me, I would go with the 65% let-off, but thats just me.
If you can, shoot some different bows with different let-offs, and take home the one that feels best in your hands. Anytime you're looking to get a new bow, you should try out as many as you can get your hands on. You may not like 80% let-off, or you may love it. But only YOU will be able to know for sure.
Good luck on the search for a new bow, and have a good one---Matt