RE: Spine and Tiller...sounds like a comedy team!
Generally I feel safe taking any bow down about 13 lbs. If I can see the bottom of the bolt I will take one down more than that. If in doubt press the bow, take the bolt all of the way out, put it in three turns and that is as low as I would take that particular bow.
Yes you should be able to error on the light side of the spine range for a medium cam. Take a look at bareshaft tuning to help select a shaft size/lenght.
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