It is obvious that bullet placement and bullet type are extremely important, but for comparison between reloads of a particular caliber for a particular animal, kenetic energy is an extremely important factor in the clean kill of an animal. Kenetic energy is based on the bullet velocity and weight which are both directly related to the penetration, performance, and killing power of a particular bullet.
The following was taken from
www.chuckhawks.com
Kinetic energy
Energy, the ability to do work (or damage in the case of a bullet fired from a rifle) is an important component of killing power. It should be obvious to practically anyone that a bullet carrying more energy when it hits the target has the potential to do more damage than a bullet carrying less energy. Energy is what powers such important functions as penetration, bullet expansion, and tissue destruction. In the U.S. it is measured in foot pounds (ft. lbs.).
Kinetic energy is the most commonly used measure of a rifle's "power." It is the figure(s) listed, along with velocity, in practically all ballistics tables. It can be computed quite easily and is essentially the product of a bullet's mass times its velocity squared. If you want to calculate a bullet's energy at home, multiply the square of its velocity (in feet per second) by the bullet's weight (in grains) and divide by 450,400.
Energy is a pretty good rough estimate of killing power as long as you are comparing two reasonably similar rifle calibers and bullets that are not too dissimilar in sectional density. Compare a 200 grain bullet fired from a .35 Remington rifle to the same bullet fired from a .350 Remington Magnum rifle and you will find that the .350 Magnum caliber rifle is more powerful--its bullet carries more energy to the target. This squares quite nicely with reality, as the .350 Rem. Mag. has proven to have greater killing power.
Compare a 130 grain bullet from a .270 rifle with a 150 grain bullet from a .30-06 rifle, using standard factory loads, and you will find that at 100 yards the .270 bullet is carrying 2225 ft. lbs. of energy and the .30-06 bullet is carrying 2281 ft. lbs. (Remington figures for Core-Lokt Pointed Soft Point bullets). The Remington Core-Lokt bullets for the two calibers are very similar in performance, and those are very similar energy figures, so you would expect the two rifles to be essentially equal in killing power. Decades of use on big game have proven that the two calibers and loads are indeed just about equal in killing power.
Kinetic energy figures can be misleading, however, if dissimilar calibers and bullets are compared. The same Remington ballistics table that provided the energy figures for the .270 and .30-06 loads above also shows that the .30-30 factory load using a 150 grain Core-Lokt bullet carries 1296 ft. lbs. of kinetic energy at 100 yards. It also shows that the Remington .22-250 factory load using a 55 grain Power-Lokt varmint bullet carries 1257 ft. lbs. of energy at 100 yards. Does that mean that the .22-250 is approximately equal to the .30-30 as a deer and general CXP2 class big game cartridge?
Absolutely not! While the energy figures are comparable, the sectional density, frontal area, penetration, bullet performance, and consequently the killing power are completely different. Experience has proven that the .30-30 with the 150 grain Core-Lokt bullet is an excellent CXP2 class game cartridge, and the .22-250 with the 55 grain Power-Lokt bullet is woefully inadequate. The .30-30 and .22-250 are too dissimilar to compare on the basis of kinetic energy.
Energy is an important, but not the only, indicator of killing power. Cartridges that do not develop adequate energy are unlikely to place very high on any rational killing power list.