JMO, but the .243 with even the lowly CoreLokt or PowerPoint is THE ticket for whitetail and pronghorns. I've had more animals drop in their tracks using the .243 than any other caliber.
My personal favorite is the 100 gr Hornady BTSP over 42.5 grains of H4350, yields just under 3000 fps, prints around .875" at 100 yards. Backed down to 41.8 grains, I can make a ragged hole with a Remington 600, and about .5" with a Ruger No. 1-B. Haven't put that one on the chrono yet, but I expect it to come in somewhere around 2875. Might just be my own experience, but the .243 does seem to be a bit more sensitive to case prep than the .223s and .30-06s I also reload for.
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