Hey Blood Trail, I hunt on my family farm in Cloud county, which is the next county to the east of Mitchell. If your friend has land with creek bottom, you should be in good shape. There are good deer numbers in that area. Be aware that upland bird season starts the second weekend of Nov., which is about the center of the rut. If your friend doesn't allow bird hunters on his land and the land around his does, that might be a good time to hunt, as the bird hunters may very well push deer onto your friends land, but if he does allow bird hunters, you need to coordinate where they hunt to where you hunt, that could work in your favor too. It is a crap shoot as when the best time to bow hunt would be, for me though, I would pick the first week of Nov. and hope to catch the deer in the "chase" phase of the rut. That is when the bucks will really be on the move looking for that first hot doe. As you may know, once a buck finds a hot doe, he may spend upto 36 hours with her, and more times than not, they will not be in an area where you'd normally find the deer.
I go through the dilima of when to go every year too. This year I am going to wait until Thanksgiving, but only because of a "bad" timing issue I have this year.
Good Luck! there are some dandy bucks in and around that part of the state!