Dr. mez,
I recently came across this research article. As you know, following surgery to repair a torn CCL, the odds of blowing the "good knee" go up a lot.
Here's an article that suggests that Fish Oil has a beneficial effect on the good knee following CCL repair.
Fish oil decreases matrix metalloproteinases in knee synovia of dogs with inflammatory joint disease. Hansen RA, Harris MA, Pluhar GE, Motta T, Brevard S, Ogilvie GK, Fettman MJ, Allen KG.[/align]Department of Health Promotion and Human Performance, Weber State University, Ogden, UT 84408, USA.
This study was designed to determine whether dietary fish oil affects the expression and activity of matrix metalloproteinases (MMP), tissue inhibitors of MMP-2 (TIMP-2) and urokinase plasminogen activator (uPA) in synovial fluid from dogs with spontaneously occurring stifle (knee) instability in a single hind limb resulting from acute cranial cruciate ligament (CCL) injury. Two groups of 12 dogs were fed diets from 1 week prior to surgery on the affected knee to 56 days post-surgery. The fish oil and control diets provided 90 and 4.5 mg, respectively, of combined eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)/kg body weight per day. Plasma and synovial fluid, from both surgical and nonsurgical knee joints, were obtained at start of the diet (-7), surgery day (0) and 7, 14, 28 and 56 days post-surgery. Plasma total EPA and DHA were significantly increased, and plasma total arachidonic acid (AA) was significantly decreased by the fish oil diet. In synovial fluid from the nonsurgical knee, fish oil treatment significantly decreased proMMP-2 expression at Days 7 and 14, and proMMP-9 expression at Day 56, and uPA activity at 28 days and significantly increased TIMP-2 expression at Days 7 and 28. There were no differences in MMP expression or activity, TIMP-2 expression and uPA activity in the surgical joint synovial fluid at any time throughout the study. These results suggest that dietary fish oil may exert beneficial effects on synovial fluid MMP and TIMP-2 equilibrium in the uninjured stifle of dogs with unilateral CCL injury.
PMID: 17531456 [PubMed - as supplied by publisher]
__________________
Ignorance can sometimes be cured, but stupid is forever.
Doc E &
HR UH MHR WR SR Black Forest Casey &
HRCH HR UH Sauk River Friar Tucker (titled at 12.5 months)
Come on Doc, you can do better than that. I don't see anywhere in that abstract that suggests that by creating equilbrium between MMP's and TIMP's that you are going to have less of a chance of rupturing a CCL. That was not the point of the study nor was it inferred by that authors. I also don't see what Fish Oil has to do with glucosamine?
Another housekeeping chore, that is an abstract for a corrected proof. The aticle has not yet been peer reviewed nor accepted for publication. The article can't be evaluated until published.
Since you like to pick and choose, here is one for you, been peer reviewed and published both:
Evidence-based practice: review of clinical evidence on the efficacy of glucosamine and chondroitin in the treatment of osteoarthritis. Distler J, Anguelouch A.Department of Family and Community Health, University of Maryland School of Nursing, Baltimore, Maryland, USA. distler@son.umaryland.edu
PURPOSE: To evaluate past and current evidence from randomized controlled trials on the efficacy of glucosamine sulfate (GS), glucosamine hydrochloride (GH), and chondroitin sulfate (CS) for the treatment of osteoarthritis (OA). DATA SOURCES: An extensive review of four meta-analyses and a review of the findings of the recently published Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT) funded by the National Institutes of Health.
FINDINGS: Review of previous studies on the efficacy of GS, GH, and CS in the treatment of OA showed inconclusive results because of weak research design.The GAIT attempted to provide clarity on the use of GH and CS in treating knee pain from OA by using a rigorous research design to elicit cause and effect. The GAIT results showed that GH and CS were not effective in reducing knee pain in the study group overall; however, these may be effective in combination for patients with moderate-to-severe knee pain.
IMPLICATIONS FOR PRACTICE: There is now clinical evidence indicating that recommending GS, GH, and CS for the treatment of mild knee pain from OA is ineffective. Further research needs to be done to identify specific characteristics in patients that results in a positive response. Until the findings of the GAIT undergo further peer review, the results of the research needs to be interpreted with caution.
I did not say anything about having less of a chance of rupturing a CCL. I said the study shows that Fish Oil is beneficial to the good knee.
I didn't see a publication date of the abstract you provided.
Since you considerevidence over 5 years old as being 'out of date', what is the newest research you can find that says that annual booster immunizations are clinically appropriate?.........Hmmmm they're all over 5 years old aren't they?
Iwould have to look for it, but I remember reading recently where some Vet Schools are now advising 3 years or even 5 years. What is your advice to clients/patientsin your practice concerning this? You aren't going by antiquated evidence are you?
BTW, I haven't pedeled anything on this site for a very long time.
I used to have a link to my supplement in my signature line -- I took it off a long time ago. The admin of this site said it was perfectly alright for me to have it here. I took it off of my own accord. I'm not trying to sell anything here.
.
__________________
Ignorance can sometimes be cured, but stupid is forever.
Doc E &
HR UH MHR WR SR Black Forest Casey &
HRCH HR UH Sauk River Friar Tucker (titled at 12.5 months)
: J Am Acad Nurse Pract. 2006 Oct;18(10):487-93.Links[/align]Evidence-based practice: review of clinical evidence on the efficacy of glucosamine and chondroitin in the treatment of osteoarthritis.About 9 months ago, fairly current.
Quote:
Since you considerevidence over 5 years old as being 'out of date', what is the newest research you can find that says that annual booster immunizations are clinically appropriate?.........Hmmmm they're all over 5 years old aren't they?
Iwould have to look for it, but I remember reading recently where some Vet Schools are now advising 3 years or even 5 years. What is your advice to clients/patientsin your practice concerning this? You aren't going by antiquated evidence are you?
Sorry, you don't got me there, I don't work on the little creatures anymore. I didn't say that evidence was out of date after 5 years. There isn't conclusive evidence on the subject. Evidence is never out of date. Once something is proven there is no need to reinvent the wheel. They have yet to prove that the neutracuetucals work. That is why there is ongoing studies, that is why Pfizer, Merial or Fort Dodge hasn't launched one and gotten it approved. People are still trying to come up with evidence.
Quote:
BTW, I haven't pedeled anything on this site for a very long time.
: J Am Acad Nurse Pract. 2006 Oct;18(10):487-93.
[/align]Evidence-based practice: review of clinical evidence on the efficacy of glucosamine and chondroitin in the treatment of osteoarthritis.About 9 months ago, fairly current.
Since this was a meta analysis, they included both the poorly done research as well as the well done research. If they would have thrown out the poorly designed studies and only have kept the well done studies, the results would have been far different.
.
__________________
Ignorance can sometimes be cured, but stupid is forever.
Doc E &
HR UH MHR WR SR Black Forest Casey &
HRCH HR UH Sauk River Friar Tucker (titled at 12.5 months)
[/align]Evidence-based practice: review of clinical evidence on the efficacy of glucosamine and chondroitin in the treatment of osteoarthritis.About 9 months ago, fairly current.
Since this was a meta analysis, they included both the poorly done research as well as the well done research. If they would have thrown out the poorly designed studies and only have kept the well done studies, the results would have been far different.
Many of the old studies use the HCL forms instead of the Sulfate forms.
It has been shown in very very new research that Chondroitin has ZERO effect in adults.
.
__________________
Ignorance can sometimes be cured, but stupid is forever.
Doc E &
HR UH MHR WR SR Black Forest Casey &
HRCH HR UH Sauk River Friar Tucker (titled at 12.5 months)
ORIGINAL: mez
Pfizer, Merial or Fort Dodge hasn't launched one and gotten it approved. People are still trying to come up with evidence.
Pfizer ? What a joke. Didn't they manufature one of the drugs (Viox and Bextra) that ended up killing 60,000 people before they were taken off the market?
Both the manufacturers of these drugs as well as the FDA called them "safe and effective". "Approval" isn't always a good thing. Are those companies really supporting any Glucosamine research? I sincerely doubt it. Not near enough profit. If they can't make 4 gazillion% profit, they don't want to sell it.
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__________________
Ignorance can sometimes be cured, but stupid is forever.
Doc E &
HR UH MHR WR SR Black Forest Casey &
HRCH HR UH Sauk River Friar Tucker (titled at 12.5 months)
Dr. Dr., literature and evidence are two differnt things. I explained it to you once, ongoing studies/research anything over 5 years old is out of date. That isn't my rule BTW, the experts in the profession you serve state that.
I can find some recent research that chondroitan sulfate is helpful in adults.
So you are saying if they didn't include poorly desingned studies then the results would have been different. That they would my friend. If they didn't include poorly designed studies there wouldn't be much of any evidence that it worked at all. The problem the western medical crowd has with the products is that the only studies to show benefit have been poor studies.
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Hey mez -- Fish Oil Protects the Good Knee
