It is "possible" to use a 22 but maybe not advisable.
Added in edit.
Hit the wrong button. While moose aren't hard to kill and I like the 243 I don't believe it is what I'd call a good match. Moose have big bones more ooomph is needed.
243 is a great moose round if your real close and hit him in the slats otherwise fughetaboutit...I know just a few lunatics that have shot Elk with 243's and recovered said animals not to consider that but it would be far removed from my first choice.
__________________
"Banning guns is an idea whose time has come."
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Associated Press 11/18/93
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It can be done. We were 35 miles into the wilderness when the horse w/ my dads rifle decided he was seabisciut and took off, then he decided to do some gymnastics, thereby snapping the stock off dads rifle. we had a 6mm along for deer and that was what he had when he found his moose, one shot down he goes, It wouldnt be my choice though.
.243 Winchester
