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ORIGINAL: 8mm/06
I have often considered a lever gun in one of the large bores...but that would be an additional animal for the cabinet....The 338/06 AI (or bigger/more potent) I would have in a bolt. (I do like the 444 and others of it's ilk) Isn't the .338 Win mag much of a boost over the 338/06?
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No, the .338 Win. is NOT much better than the .338/'06! BUT, the .340 Weatherby is, if you wish to stay under .375" bore size. You should consider the .375 H&H or even the recently reintroduced .375 Weatherby, which is a little more powerful than the regular H&H, but is still shootable. The .378 Weatherby is pretty much the "king" of the .375" bores, but is a real pain to shoot. I mean PAIN in the most literal sense of the word, too!
If you go for a lever gun, avoid the .444 Marlin
unless you want to use Buffalo Bore ammo, or you load your own, since the big factories use what are essentially pistol bullets in this caliber, with low sectional densities and relatively poor penetration. These bullets pretty much relegate the .444 to a deer/black bear load. However, using heavy hard-cast flatnose bullets, the .444 definitely moves up into the "serious cartridge" class!
I personally believe the .45/70 to be the most versatile big-bore lever action cartridge.