Pick the .270 ... the 22-250 for deer is a little on the small side. You might want to look at the .243 if you are only want one rifle. The .243 has a wide range of loads to buy and is not a bad little deer rifle.
A 90 grain bullet from a .270 is a sight to behold when it hits something solid. A 270 will almost do it all.....and you can use light enough bullets to varmint.....just dont try to save the pelts...lol.
Definetly the .270. It will handle anything from moose down to chucks and do it well. It is definetly one of the most versatile catridges made.
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If those are your only two choices, go with the 270. But, like downwind said, the 243 may be the best round to fit the bill. The 22-250 will kill deer, but I think that we owe too much respect to the deer to use a "marginal" caliber. just my .02
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T/C!! If you need more than one shot, you need more practice!
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.270 or 22-250
