Just picked up a new gun today, Ruger 454 Casull (7.5"barrel)

I've owned a few handguns but not one just for hunting. I put a used Bushnell 3x6.5x32 glass on for now thinking I can always up grade closer to the hunting season. My question is where to begin with the sight in as far as the yardage goes? Is it the same as a rifle sight in and what load is the most popular?
I picked up a box of 260gr 45 colt ammo just for getting use to the recoil and Hornady 454 300gr JHP/XTP for hunting. Are these choices good? or would anyone care to make a recommendation on what ammo you use. Any help would be appreciated

Deer, bear and a few coyotes crossing my path are what I'll be hunting when the time comes. Thanks for any help......MK-M-GOBL